Which layer is primarily responsible for the structural integrity of the skin?

The dermis is the layer of skin that provides structural integrity. It is located beneath the epidermis and contains a dense network of collagen and elastin fibers, which contribute to the skin's strength, elasticity, and overall resilience. The dermis also houses essential components such as blood vessels, nerve endings, hair follicles, and glands, all of which support the skin's functions and help maintain its integrity.

In contrast, the epidermis serves primarily as a protective barrier against environmental damage and water loss, while the hypodermis, also known as the subcutaneous layer, functions mainly as fat storage and insulation rather than contributing to the skin's structural framework. The stratum granulosum is a specific layer within the epidermis involved in keratinocyte maturation and does not play a role in the overall structural support of the skin. Hence, the dermis is paramount when discussing the skin's structural integrity.